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Acrodermatitis chronica atrophicans (ACA) (also known as "Herxheimer disease" and "Primary diffuse atrophy") is a skin rash indicative of the third or late stage of European Lyme borreliosis. ACA is a dermatological condition that takes a chronically progressive course and finally leads to a widespread atrophy of the skin. Involvement of the peripheral nervous system is often observed, specifically polyneuropathy. This progressive skin process is due to the effect of continuing active infection with the spirochete Borrelia afzelii, which is the predominant pathophysiology. ''B. afzelii'' may not be the exclusive etiologic agent of ACA; ''Borrelia garinii'' has also been detected. ==Presentation== The rash caused by ACA is most evident on the extremities. It begins with an inflammatory stage with bluish red discoloration and cutaneous swelling, and concludes several months or years later with an atrophic phase. Sclerotic skin plaques may also develop. As ACA progresses the skin begins to wrinkle. 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「acrodermatitis chronica atrophicans」の詳細全文を読む スポンサード リンク
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